Reaction: ING2-bound EP300 acetylates TP53
- in pathway: PI5P Regulates TP53 Acetylation
The histone acetyltransferase EP300 (p300), recruited to TP53 (p53) by ING2, acetylates TP53 on lysine residue K382, which may contribute to TP53-dependent apoptosis (Padeux et al. 2005). PI5P positively regulates TP53 acetylation (Zou et al. 2007), possibly by increasing the amount of ING2 in the nucleus (Gozani et al. 2003).
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-6811508
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-6811508