Reaction: NatC acetylates ARFFRP1
- in pathway: Retrograde transport at the Trans-Golgi-Network
ARFRP1 is an ARF family member GTPase that recruits ARL1 to the trans-Golgi network to play roles in retrograde trafficking of proteins from the endolysosomal system. ARFRP1 is an atypical ARF family member in that it is not myristolated, but is instead acetylated at the amino-terminal methionine by the NatC complex. Acetylation is required for the interaction of ARFRP1 with SYS1, which contributes to its targeting to its TGN (Behnia et al, 2004; Setty et al, 2004).
Reaction - small molecule participants:
CoA-SH [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-6814090
======
Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-6814090