Reaction: GDPD3 hydrolyzes LysoPtdCho
- in pathway: Glycerophospholipid catabolism
GDPD3 (Glycerophosphodiester phosphodiesterase domain-containing protein 3, also known as GDE7 - Glycerophosphodiester phosphodiesterase 7) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human protein has been characterized only to a limited extent; its enzymatic activity and predominant intracellular localization are inferred from in vitro studies of the recombinant homologous mouse protein (Oshima et al. 2015).
Reaction - small molecule participants:
GPCho [cytosol]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
LysoPtdCho [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-6814778
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Reaction input - small molecules:
water
1-O-acyl-sn-glycero-3-phosphocholine
Reaction output - small molecules:
choline alfoscerate
long-chain fatty acid anion
Reactome.org link: R-HSA-6814778