Reaction: Removal of RNA primer and dissociation of RPA and Dna2
- in pathway: Removal of the Flap Intermediate
The Dna2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and Dna2. The current data for the role of the Dna2 endonuclease has been derived from studies with yeast and Xenopus Dna2.
Reaction - small molecule participants:
UMP [nucleoplasm]
AMP [nucleoplasm]
GMP [nucleoplasm]
CMP [nucleoplasm]
Reactome.org reaction link: R-HSA-69144
======
Reaction input - small molecules:
Reaction output - small molecules:
uridine 5'-monophosphate(2-)
adenosine 5'-monophosphate(2-)
guanosine 5'-monophosphate(2-)
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-69144