Reaction: Phosphorylation of Cyclin E:CDK2 complexes by WEE1
- in pathway: Cyclin E associated events during G1/S transition
WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). WEE1-mediated phosphorylation of CDK2 is enhanced in the presence of CABLES1, which can form a complex with CDK2 bound to cyclin E (CCNE) or cyclin A (CCNA) (Wu et al. 2001).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-69195
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-69195