Reaction: Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).
Reaction - small molecule participants:
Pi [cytosol]
Fru(6)P [cytosol]
H2O [cytosol]
D-Fructose 2,6-bisphosphate [cytosol]
Reactome.org reaction link: R-HSA-70262
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Reaction input - small molecules:
water
beta-D-fructofuranose 2,6-bisphosphate
Reaction output - small molecules:
hydrogenphosphate
beta-D-fructofuranose 6-phosphate(2-)
Reactome.org link: R-HSA-70262