Reaction: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
- in pathway: Glycolysis
Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).
Reaction - small molecule participants:
Fru(6)P [cytosol]
G6P [cytosol]
Reactome.org reaction link: R-HSA-70471
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Reaction input - small molecules:
alpha-D-glucose 6-phosphate(2-)
Reaction output - small molecules:
beta-D-fructofuranose 6-phosphate(2-)
Reactome.org link: R-HSA-70471