Reaction: FBP tetramers hydrolyze F1,6PP to Fru(6)P
- in pathway: Gluconeogenesis
Cytosolic FBP (fructose-1,6-bisphosphatase) tetramers catalyze the physiologically irreversible hydrolysis of F1,6PP (fructose-1,6-bisphosphate) to form Fru(6)P (fructose-6-phosphate) and Pi (orthophosphate). In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).
Reaction - small molecule participants:
Pi [cytosol]
Fru(6)P [cytosol]
F1,6PP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-70479
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Reaction input - small molecules:
beta-D-fructofuranose 1,6-bisphosphate(4-)
water
Reaction output - small molecules:
hydrogenphosphate
beta-D-fructofuranose 6-phosphate(2-)
Reactome.org link: R-HSA-70479