Reaction: carbamoyl phosphate + ornithine => citrulline + orthophosphate
- in pathway: Urea cycle
Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).
Reaction - small molecule participants:
L-Cit [mitochondrial matrix]
Pi [mitochondrial matrix]
CAP [mitochondrial matrix]
L-Orn [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70560
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Reaction input - small molecules:
carbamoyl phosphate(2-)
L-ornithinium(1+)
Reaction output - small molecules:
L-citrulline zwitterion
hydrogenphosphate
Reactome.org link: R-HSA-70560