Reaction: arginine + H2O => ornithine + urea [ARG1]
- in pathway: Urea cycle
Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).
Reaction - small molecule participants:
Urea [cytosol]
L-Orn [cytosol]
H2O [cytosol]
L-Arg [cytosol]
Reactome.org reaction link: R-HSA-70569
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Reaction input - small molecules:
water
L-argininium(1+)
Reaction output - small molecules:
urea
L-ornithinium(1+)
Reactome.org link: R-HSA-70569