Reaction: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
- in pathway: Aspartate and asparagine metabolism
Cytosolic asparagine synthase (ASNS) catalyzes the reaction of aspartate, glutamine, and ATP to form asparagine, glutamate, AMP, and pyrophosphate. Studies of the recombinant protein expressed in E. coli suggest that the active form of the enzyme is a dimer (Van Heeke and Schuster 1989).
Reaction - small molecule participants:
PPi [cytosol]
L-Glu [cytosol]
L-Asn [cytosol]
AMP [cytosol]
H2O [cytosol]
ATP [cytosol]
L-Asp [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-70599
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Reaction input - small molecules:
water
ATP(4-)
L-aspartate(1-)
L-glutamine zwitterion
Reaction output - small molecules:
diphosphate(3-)
L-glutamate(1-)
L-asparagine zwitterion
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-70599