Reaction: glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
- in pathway: Glutamate and glutamine metabolism
Cytosolic glutamine synthetase (glutamate-ammonia ligase - GLUL) catalyzes the reaction of glutamate, ammonia, and ATP to form glutamine, ADP, and orthophosphate. The enzyme is a decamer (Krajewski et al. 2008). Mutations in the gene encoding GLUL cause glutamine deficiency in vivo (Haberle et al. 2005).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
L-Gln [cytosol]
L-Glu [cytosol]
ATP [cytosol]
NH4+ [cytosol]
Pi [cytosol]
ADP [cytosol]
L-Gln [cytosol]
L-Glu [cytosol]
ATP [cytosol]
NH4+ [cytosol]
Reactome.org reaction link: R-HSA-70606
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Reaction input - small molecules:
L-glutamate(1-)
ATP(4-)
ammonium
L-glutamate(1-)
ATP(4-)
ammonium
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
L-glutamine zwitterion
hydrogenphosphate
ADP(3-)
L-glutamine zwitterion
Reactome.org link: R-HSA-70606