Reaction: tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA
- in pathway: Branched-chain amino acid catabolism
Mitochondrial tiglyl-CoA is hydrolyzed to form alpha-methyl-beta-hydroxybutyryl-CoA. While crude extracts of human liver cells have been shown to catalyze the reaction, the specific enzyme responsible for it has not been identified (Sweetman and Williams 2001).
Reaction - small molecule participants:
aMbHBUT-CoA [mitochondrial matrix]
tiglyl-CoA [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70830
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Reaction input - small molecules:
2-methylcrotonoyl-CoA
water
Reaction output - small molecules:
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA
Reactome.org link: R-HSA-70830