Reaction: beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
- in pathway: Branched-chain amino acid catabolism
Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
bHIBA [mitochondrial matrix]
bHIB-CoA [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70881
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Reaction input - small molecules:
(S)-3-hydroxyisobutyryl-CoA
water
Reaction output - small molecules:
coenzyme A(4-)
3-hydroxyisobutyrate
Reactome.org link: R-HSA-70881