Reaction: urocanate + H2O => 4-imidazolone-5-propionate
- in pathway: Histidine catabolism
Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).
Reaction - small molecule participants:
4I-5PROA [cytosol]
H2O [cytosol]
UCA [cytosol]
Reactome.org reaction link: R-HSA-70903
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Reaction input - small molecules:
water
trans-urocanic acid
Reaction output - small molecules:
3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid
Reactome.org link: R-HSA-70903