Reaction: 4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
- in pathway: Histidine catabolism
Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).
Reaction - small molecule participants:
NF-Glu [cytosol]
H+ [cytosol]
H2O [cytosol]
4I-5PROA [cytosol]
Reactome.org reaction link: R-HSA-70906
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Reaction input - small molecules:
water
3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid
Reaction output - small molecules:
N-formimidoyl-L-glutamate(2-)
hydron
Reactome.org link: R-HSA-70906