Reaction: saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
- in pathway: Lysine catabolism
The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of saccharopine (N6-(L-1,3-Dicarboxypropyl)-L-lysine), H2O, and NAD+ to form 'L-2-Aminoadipate 6-semialdehyde, glutamate, and NADH + H+ (Markovitz et al. 1984; Sacksteder et al. 2001).
Reaction - small molecule participants:
H+ [mitochondrial matrix]
2AMAS [mitochondrial matrix]
NADH [mitochondrial matrix]
L-Glu [mitochondrial matrix]
NAD+ [mitochondrial matrix]
H2O [mitochondrial matrix]
SACN [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70940
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Reaction input - small molecules:
NAD(1-)
water
L-saccharopine
Reaction output - small molecules:
hydron
L-allysine zwitterion
NADH(2-)
L-glutamate(1-)
Reactome.org link: R-HSA-70940