Reaction: alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
- in pathway: Lysine catabolism
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).
Reaction - small molecule participants:
H+ [mitochondrial matrix]
2AMA [mitochondrial matrix]
NADH [mitochondrial matrix]
NAD+ [mitochondrial matrix]
2AMAS [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70941
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Reaction input - small molecules:
NAD(1-)
L-allysine zwitterion
water
Reaction output - small molecules:
hydron
L-2-aminoadipate(1-)
NADH(2-)
Reactome.org link: R-HSA-70941