Reaction: citrate <=> isocitrate
- in pathway: Citric acid cycle (TCA cycle)
Mitochondrial aconitase reversibly converts citrate to isocitrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).
Reaction - small molecule participants:
ISCIT [mitochondrial matrix]
CIT [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70971
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Reaction input - small molecules:
citric acid
Reaction output - small molecules:
D-threo-isocitrate(3-)
Reactome.org link: R-HSA-70971