Reaction: Fumarate + H2O <=> (S)-Malate
- in pathway: Citric acid cycle (TCA cycle)
Mitochondrial fumarate hydratase catalyzes the reversible reaction of fumarate and water to form malate, the seventh step of the TCA cycle (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).
Reaction - small molecule participants:
MAL [mitochondrial matrix]
FUMA [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-70982
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Reaction input - small molecules:
fumaric acid
water
Reaction output - small molecules:
(S)-malate(2-)
Reactome.org link: R-HSA-70982