Reaction: p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
- in pathway: Tyrosine catabolism
Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD) catalyzes the reaction of 3-(4-Hydroxyphenyl)pyruvate with molecular oxygen to form homogentisate and CO2 (Ruetschi et al. 2000, Lindblad et al. 1970). Unpublished crystallographic data indicate that the enzyme is a homodimer (PDB 3ISQ) utilising Fe2+ and ascorbate (AscH-).
Reaction - small molecule participants:
CO2 [cytosol]
HGTA [cytosol]
O2 [cytosol]
HPPYRA [cytosol]
Reactome.org reaction link: R-HSA-71163
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Reaction input - small molecules:
dioxygen
4-hydroxyphenylpyruvic acid
Reaction output - small molecules:
carbon dioxide
homogentisate
Reactome.org link: R-HSA-71163