Reaction: homogentisate + O2 => maleylacetoacetate
- in pathway: Tyrosine catabolism
Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the reaction of homogentisate and molecular oxygen to form 4-maleylacetoacetate. The activity of human HGD is inferred from the phenotype of alkaptonuria patients, in whom HGD activity is defective (Fernandez-Canon et al. 1996). HGD is a homohexamer (Titus et al. 2000).
Reaction - small molecule participants:
4MAA [cytosol]
O2 [cytosol]
HGTA [cytosol]
Reactome.org reaction link: R-HSA-71164
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Reaction input - small molecules:
dioxygen
homogentisate
Reaction output - small molecules:
4-maleylacetoacetate
Reactome.org link: R-HSA-71164