Reaction: 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
- in pathway: Tryptophan catabolism
This reaction has been characterized in vitro using enzyme partially purified from cat liver (Ichiyama et al. 1965). The human event is inferred from the cat one. Neither the cat nor the human protein has been fully purified or sequenced.
Reaction - small molecule participants:
H+ [cytosol]
2AM [cytosol]
NADH [cytosol]
2AMA [cytosol]
H2O [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-71239
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Reaction input - small molecules:
2-aminomuconic 6-semialdehyde zwitterion
water
NAD(1-)
Reaction output - small molecules:
hydron
(2Z,4E)-2-ammoniomuconate(1-)
NADH(2-)
Reactome.org link: R-HSA-71239