Reaction: ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
- in pathway: Pentose phosphate pathway
Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-xylulose 5-phosphate and D-ribose 5-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Reaction - small molecule participants:
SH7P [cytosol]
GA3P [cytosol]
XY5P [cytosol]
R5P [cytosol]
Reactome.org reaction link: R-HSA-71324
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Reaction input - small molecules:
D-xylulose 5-phosphate(2-)
D-ribofuranose 5-phosphate(2-)
Reaction output - small molecules:
sedoheptulose 7-phosphate
D-glyceraldehyde 3-phosphate(2-)
Reactome.org link: R-HSA-71324