Reaction: xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
- in pathway: Pentose phosphate pathway
Cytosolic transketolase (TKT) catalyzes the reaction of D-erythrose 4-phosphate and D-xylulose 5-phosphate to form D-glyceraldehyde 3-phosphate and D-fructose 6-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Reaction - small molecule participants:
GA3P [cytosol]
Fru(6)P [cytosol]
XY5P [cytosol]
E4P [cytosol]
Reactome.org reaction link: R-HSA-71335
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Reaction input - small molecules:
D-xylulose 5-phosphate(2-)
D-erythrose 4-phosphate(2-)
Reaction output - small molecules:
D-glyceraldehyde 3-phosphate(2-)
beta-D-fructofuranose 6-phosphate(2-)
Reactome.org link: R-HSA-71335