Reaction: Aldolase tetramers convert GA3P and DHAP to F1,6PP
- in pathway: Gluconeogenesis
In this freely reversible cytosolic reaction, DHAP (dihydroxyacetone phosphate) and GA3P (D-glyceraldehyde 3-phosphate) react to form F1,6PP (D-fructose 1,6-bisphosphate). The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).
Reaction - small molecule participants:
F1,6PP [cytosol]
GA3P [cytosol]
DHAP [cytosol]
Reactome.org reaction link: R-HSA-71495
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Reaction input - small molecules:
D-glyceraldehyde 3-phosphate(2-)
glycerone phosphate(2-)
Reaction output - small molecules:
beta-D-fructofuranose 1,6-bisphosphate(4-)
Reactome.org link: R-HSA-71495