Reaction: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
- in pathway: Glycolysis
Cytosolic aldolase catalyzes the cleavage of D-fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. The active form of aldolase is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Freemont et al. 1984, 1988).
Reaction - small molecule participants:
GA3P [cytosol]
DHAP [cytosol]
F1,6PP [cytosol]
Reactome.org reaction link: R-HSA-71496
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Reaction input - small molecules:
beta-D-fructofuranose 1,6-bisphosphate(4-)
Reaction output - small molecules:
D-glyceraldehyde 3-phosphate(2-)
glycerone phosphate(2-)
Reactome.org link: R-HSA-71496