Reaction: acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
- in pathway: Ethanol oxidation
ALDH1A1 (aldehyde dehydrogenase) in the cytosol catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Inoue et al. 1979). The active form of the enzyme is a tetramer (Ni et al. 1999).
Reaction - small molecule participants:
H+ [cytosol]
CH3COO- [cytosol]
NADH [cytosol]
H2O [cytosol]
CH3CHO [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-71691
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Reaction input - small molecules:
water
acetaldehyde
NAD(1-)
Reaction output - small molecules:
hydron
acetic acid
NADH(2-)
Reactome.org link: R-HSA-71691