Reaction: acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
- in pathway: Ethanol oxidation
ALDH2 (aldehyde dehydrogenase) in the mitochondrial matrix catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Greenfield and Pietruszko 1977; Hempel et al. 1985). The active form of the enzyme is a tetramer (Ni et al. 1999).
Reaction - small molecule participants:
H+ [mitochondrial matrix]
NADH [mitochondrial matrix]
CH3COO- [mitochondrial matrix]
CH3CHO [mitochondrial matrix]
NAD+ [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-71723
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Reaction input - small molecules:
acetaldehyde
NAD(1-)
water
Reaction output - small molecules:
hydron
NADH(2-)
acetate
Reactome.org link: R-HSA-71723