Reaction: PPA1 hydrolyzes pyrophosphate to orthophosphate
- in pathway: Pyrophosphate hydrolysis
Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme, a homodimer, requires Mg++ for activity (Fisher et al. 1974; Pynes and Younathan 1967; Thuiller et al. 1978).
Reaction - small molecule participants:
Pi [cytosol]
PPi [cytosol]
H2O [cytosol]
Pi [cytosol]
PPi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-71732
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Reaction input - small molecules:
diphosphate(3-)
water
diphosphate(3-)
water
Reaction output - small molecules:
hydrogenphosphate
hydrogenphosphate
Reactome.org link: R-HSA-71732