Reaction: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
- in pathway: Ethanol oxidation
Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).
Reaction - small molecule participants:
PPi [cytosol]
Ac-CoA [cytosol]
AMP [cytosol]
ATP [cytosol]
CH3COO- [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-71735
======
Reaction input - small molecules:
ATP(4-)
acetic acid
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
acetyl-CoA(4-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-71735