Reaction: G6PC hydrolyzes G6P to Glc and Pi (liver)
- in pathway: Gluconeogenesis
Glucose-6-phosphatase (G6PC) associated with the inner face of the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose (Glc) and orthophosphate (Pi). This reaction is essentially irreversible (Lei et al. 1993, Ghosh et al. 2002). Defects in G6PC are the cause of glycogen storage disease type 1a (Lei et al. 1993, 1995, Chou and Mansfield 2008).
Reaction - small molecule participants:
Pi [endoplasmic reticulum lumen]
Glc [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
G6P [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-71825
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Reaction input - small molecules:
water
alpha-D-glucose 6-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
alpha-D-glucose
Reactome.org link: R-HSA-71825