Reaction: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP
- in pathway: Glycolysis
Cytosolic phosphoglycerate kinase (PGK) catalyzes the reaction of ADP and 1,3-bisphosphoglycerate (1,3BPG) to form D glyceraldehyde 3-phosphate (3PG) and ATP. The active form of the enzyme is a monomer and requires Mg++ (Yoshida and Watanabe 1972; Huang et al. 1980a,b). This is the first substrate level phosphorylation reaction in glycolysis. Two PGK isoforms are known: PGK1 is widely expressed in the body while PGK2 (Chen et al. 1976; McCarrey & Thomas 1987) appears to be confined to sperm cells.
Reaction - small molecule participants:
ATP [cytosol]
3PG [cytosol]
ADP [cytosol]
1,3BPG [cytosol]
Reactome.org reaction link: R-HSA-71850
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Reaction input - small molecules:
ADP(3-)
3-phosphonato-D-glyceroyl phosphate(4-)
Reaction output - small molecules:
ATP(4-)
3-phosphonato-D-glycerate(3-)
Reactome.org link: R-HSA-71850