Reaction: Cap-bound mRNA is activated by helicases
- in pathway: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
The DEAD-box RNA helicase eIF4A, together with the RNA-binding proteins eIF4B or eIF4H, is thought to unwind RNA secondary structures near the 5'-end of the mRNA and in the presence of ATP.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-72647
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-72647