Reaction: SLC33A1 transports Ac-CoA from cytosol to Golgi lumen
The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori et al. 1997). Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that O-acetylates sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin et al. 2008).
Reaction - small molecule participants:
Ac-CoA [Golgi lumen]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-727759
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
acetyl-CoA(4-)
Reactome.org link: R-HSA-727759