Reaction: SLC35A1 exchanges CMP-Neu5Ac for CMP
- in pathway: Sialic acid metabolism
The human gene SLC35A1 encodes the CMP-sialic acid transporter which mediates the antiport of CMP-sialic acid (CMP-Neu5Ac) into the Golgi lumen in exchange for CMP (Ishida et al. 1996). Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F; MIM:603585). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation (Martinez-Duncker et al. 2005).
Reaction - small molecule participants:
CMP-Neu5Ac [Golgi lumen]
CMP [cytosol]
CMP [Golgi lumen]
CMP-Neu5Ac [cytosol]
CMP-Neu5Ac [Golgi lumen]
CMP [cytosol]
CMP [Golgi lumen]
CMP-Neu5Ac [cytosol]
Reactome.org reaction link: R-HSA-727807
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Reaction input - small molecules:
cytidine 5'-monophosphate(2-)
CMP-N-acetyl-beta-neuraminate(2-)
cytidine 5'-monophosphate(2-)
CMP-N-acetyl-beta-neuraminate(2-)
Reaction output - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
cytidine 5'-monophosphate(2-)
CMP-N-acetyl-beta-neuraminate(2-)
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-727807