Reaction: CAD hexamer transforms L-Gln to CAP
- in pathway: Pyrimidine biosynthesis
The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).
Reaction - small molecule participants:
CAP [cytosol]
Pi [cytosol]
L-Glu [cytosol]
H+ [cytosol]
ADP [cytosol]
H2O [cytosol]
HCO3- [cytosol]
ATP [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-73577
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Reaction input - small molecules:
water
hydrogencarbonate
ATP(4-)
L-glutamine zwitterion
Reaction output - small molecules:
carbamoyl phosphate(2-)
hydrogenphosphate
L-glutamate(1-)
hydron
ADP(3-)
Reactome.org link: R-HSA-73577