Reaction: dCMP + H2O => dUMP + NH4+
- in pathway: Interconversion of nucleotide di- and triphosphates
Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hydrolysis of dCMP (2'-deoxyuridine 5'-monophosphate) to yield dUMP (2'-deoxyuridine 5'-monophosphate) and ammonia. The active enzyme is a homohexamer (Maley et al. 1993; Weiner et al. 1993; unpublished crystallography data - PDB 2W4L).
Reaction - small molecule participants:
dUMP [cytosol]
NH4+ [cytosol]
H2O [cytosol]
H+ [cytosol]
dCMP [cytosol]
Reactome.org reaction link: R-HSA-73596
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Reaction input - small molecules:
water
hydron
2'-deoxycytosine 5'-monophosphate(2-)
Reaction output - small molecules:
dUMP(2-)
ammonium
Reactome.org link: R-HSA-73596