Reaction: UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]
- in pathway: Interconversion of nucleotide di- and triphosphates
Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
Reaction - small molecule participants:
Pi [cytosol]
L-Glu [cytosol]
H+ [cytosol]
ADP [cytosol]
CTP [cytosol]
H2O [cytosol]
ATP [cytosol]
UTP [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-73647
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Reaction input - small molecules:
water
ATP(4-)
UTP(4-)
L-glutamine zwitterion
Reaction output - small molecules:
hydrogenphosphate
L-glutamate(1-)
hydron
ADP(3-)
CTP(4-)
Reactome.org link: R-HSA-73647