Reaction: dUTP + H2O => dUMP + pyrophosphate
- in pathway: Interconversion of nucleotide di- and triphosphates
Deoxyuridine triphosphatase (DUT) catalyzes the hydrolysis of dUTP to form dUMP and pyrophosphate. Two isoforms of DUT are expressed, generated by alternative splicing. The major one, annotated here, is localized to the nucleoplasm (Ladner et al. 1996). The enzyme is a homotrimer (Mol et al. 1996). In the cell, this reaction depletes the supply of dUTP, preventing its incorporation into DNA, while generating dUMP, the immediate precursor of thymidine nucleotides.
Reaction - small molecule participants:
H+ [nucleoplasm]
PPi [nucleoplasm]
dUMP [nucleoplasm]
H2O [nucleoplasm]
dUTP [nucleoplasm]
Reactome.org reaction link: R-HSA-73666
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Reaction input - small molecules:
water
dUTP(4-)
Reaction output - small molecules:
hydron
diphosphate(3-)
dUMP(2-)
Reactome.org link: R-HSA-73666