Reaction: Acetylation of SL1
- in pathway: RNA Polymerase I Transcription Initiation
Acetylation of the TAFI63 subunit of SL1 by PCAF stimulates the association of TAFI63 with DNA and stimulates pol I transcription in vitro. Conversely, deacetylation by the NAD+-dependent deacetylase Sir2 represses pol I transcription.
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-73736
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-73736