Reaction: XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
- in pathway: Purine ribonucleoside monophosphate biosynthesis
Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).
Reaction - small molecule participants:
PPi [cytosol]
L-Glu [cytosol]
H+ [cytosol]
GMP [cytosol]
AMP [cytosol]
H2O [cytosol]
ATP [cytosol]
XMP [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-73792
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Reaction input - small molecules:
water
ATP(4-)
5'-xanthylate(2-)
L-glutamine zwitterion
Reaction output - small molecules:
diphosphate(3-)
L-glutamate(1-)
hydron
guanosine 5'-monophosphate(2-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-73792