Reaction: FAICAR => IMP + H2O
- in pathway: Purine ribonucleoside monophosphate biosynthesis
The reversible synthesis of inosine 5'-monophosphate from 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) is catalyzed by the IMP cyclohydrolase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).
Reaction - small molecule participants:
H2O [cytosol]
IMP [cytosol]
FAICAR [cytosol]
Reactome.org reaction link: R-HSA-73797
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Reaction input - small molecules:
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Reaction output - small molecules:
water
IMP(2-)
Reactome.org link: R-HSA-73797