Reaction: adenylosuccinate => adenosine 5'-monophosphate + fumarate
- in pathway: Purine ribonucleoside monophosphate biosynthesis
The irreversible conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993). The enzyme also catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).
Reaction - small molecule participants:
FUMA [cytosol]
AMP [cytosol]
ADS [cytosol]
Reactome.org reaction link: R-HSA-73828
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Reaction input - small molecules:
N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)
Reaction output - small molecules:
fumarate(2-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-73828