Reaction: acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+
- in pathway: Synthesis of Ketone Bodies
D-beta-hydroxybutyrate dehydrogenase tetramer (BDH1) in the mitochondrial matris catalyzes the reversible reaction of acetoacetate with NADH + H+ to form D-beta hydroxybutyrate and NAD+ (Marks et al. 1992).
Reaction - small molecule participants:
NAD+ [mitochondrial matrix]
bHBA [mitochondrial matrix]
H+ [mitochondrial matrix]
ACA [mitochondrial matrix]
NADH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-73912
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Reaction input - small molecules:
hydron
acetoacetic acid
NADH(2-)
Reaction output - small molecules:
NAD(1-)
(R)-3-hydroxybutyric acid
Reactome.org link: R-HSA-73912