Reaction: 2 acetyl-CoA <=> acetoacetyl-CoA + CoA
- in pathway: Synthesis of Ketone Bodies
Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of two molecules of acetyl-CoA to form acetoacetyl-CoA and CoA (Middleton et al. 1986).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
ACA-CoA [mitochondrial matrix]
Ac-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-73916
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
acetoacetyl-CoA(4-)
Reactome.org link: R-HSA-73916