Reaction: acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
- in pathway: Synthesis of Ketone Bodies
Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
HMG CoA [mitochondrial matrix]
ACA-CoA [mitochondrial matrix]
Ac-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-73918
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Reaction input - small molecules:
acetoacetyl-CoA(4-)
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
(3S)-3-hydroxy-3-methylglutaryl-CoA
Reactome.org link: R-HSA-73918