Reaction: D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+
- in pathway: Utilization of Ketone Bodies
D-beta-hydroxybutyrate dehydrogenase tetramer (BDH1) in the mitochondrial matrix catalyzes the reversible reaction of D-beta hydroxybutyrate and NAD+ to form acetoacetate and NADH + H+ (Marks et al. 1992).
Reaction - small molecule participants:
H+ [mitochondrial matrix]
ACA [mitochondrial matrix]
NADH [mitochondrial matrix]
NAD+ [mitochondrial matrix]
bHBA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-73920
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Reaction input - small molecules:
NAD(1-)
(R)-3-hydroxybutyric acid
Reaction output - small molecules:
hydron
acetoacetic acid
NADH(2-)
Reactome.org link: R-HSA-73920