Reaction: cGMP binds CNG channel to form cGMP:CNG channel
Once cGMP concentration is restored to "dark" levels, it binds cooperatively to the cGMP-gated cation channel (CNG channel), inducing opening through a conformational change in the channel (open status designated as cGMP:CNG channel here) (Chen et al 1993, Dhallan et al. 1992).
Reaction - small molecule participants:
cGMP [cytosol]
Reactome.org reaction link: R-HSA-74031
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Reaction input - small molecules:
3',5'-cyclic GMP
Reaction output - small molecules:
Reactome.org link: R-HSA-74031