Reaction: HMG CoA => acetoacetic acid + acetyl CoA
- in pathway: Synthesis of Ketone Bodies
Hydroxymethylglutaryl-CoA lyase dimer (HMGCL) in the mitochondrial matrix catalyzes the reaction of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) to form acetyl-CoA and acetoacetate (Mitchell et al. 1993).
Reaction - small molecule participants:
Ac-CoA [mitochondrial matrix]
ACA [mitochondrial matrix]
HMG CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-74180
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Reaction input - small molecules:
(3S)-3-hydroxy-3-methylglutaryl-CoA
Reaction output - small molecules:
acetyl-CoA(4-)
acetoacetic acid
Reactome.org link: R-HSA-74180